Compound reference
CJC-1295 No DAC: structure and analysis
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CJC-1295 No DAC is a ghrh analog supplied for laboratory research. Its molecular formula is C165H269N47O46, with an average molecular weight of 3647.2 g/mol and a monoisotopic mass of 3645.015 Da. This page covers its structure, how it is produced, and how identity and purity are established — for a batch, on that batch's certificate of analysis.
What is CJC-1295 No DAC?
CJC-1295 without DAC — also written as modified GRF(1-29) — is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone, carrying four amino acid substitutions and no drug-affinity complex.
The four substitutions are the point of the molecule: each replaces a residue at a site where the native sequence is vulnerable to enzymatic cleavage or chemical rearrangement, so the analog is more robust than the unmodified fragment.
The absence of the drug-affinity complex is what distinguishes this compound from the DAC-bearing version, and the two are frequently confused in this category.
How is CJC-1295 No DAC produced?
Assembled by solid-phase peptide synthesis: the chain is built one residue at a time on an insoluble resin support, then cleaved from the resin, deprotected and purified — most commonly by reversed-phase high-performance liquid chromatography. The purified material is lyophilized to a dry solid.
The impurity profile that appears on a certificate is a record of where that process was imperfect: deletion sequences from an incomplete coupling, truncated chains, and species retaining a protecting group.
What are the molecular figures for CJC-1295 No DAC?
Calculated from the formula C165H269N47O46, not measured. The average molecular weight counts the natural abundance of each element's isotopes; the monoisotopic mass is the mass of the single most abundant isotopic composition, which is the figure a mass spectrometer is usually compared against.
Two masses describe this molecule and they are not the same number. The monoisotopic mass assumes every carbon is carbon-12; the tallest peak in the isotope envelope sits 1 carbon-13 substitution above it, because for a molecule with 165 carbons that is the most probable composition. A specification or a database quoting the higher figure is not necessarily wrong — it is quoting the other peak, and both are given here.
Adducts, salts, modifications and multiply charged species all move an observed m/z away from any figure calculated here, and a certificate reports what was measured for a batch rather than what was expected of it.
What is the sequence of CJC-1295 No DAC?
No one-letter amino-acid sequence is published for CJC-1295 No DAC on this page. The analog carries four substitutions and a modification that one-letter notation does not express without inventing symbols.
What establishes the material in a specific vial is the identity method and result stated on that batch's certificate, not a notation on a reference page.
How does CJC-1295 No DAC compare with related compounds?
Related compounds are not interchangeable. Published figures differ between them, and in this catalogue three compounds share a GHRH backbone while several share the same structural class — which is exactly why identity is confirmed analytically rather than inferred from the label.
How is the identity of CJC-1295 No DAC confirmed?
Mass spectrometry distinguishes this compound from both native GHRH(1-29) and the DAC-bearing variant. The four substitutions shift the expected mass relative to the native fragment, and the absence of the drug-affinity complex shifts it substantially relative to the DAC form.
That second distinction is a large mass difference, which makes it an easy confirmation to perform and an unambiguous one to read — and therefore a poor thing for a supplier to leave undocumented.
Which impurities can appear in CJC-1295 No DAC?
At 29 residues this is a long synthetic peptide, so deletion and truncation sequences are the expected impurity class and chromatographic resolution of closely related species matters more than it does for a short chain.
Because three compounds in this catalogue are built on the GHRH sequence — this one, sermorelin and tesamorelin — the identity result is what establishes which of them is in a given vial. They are not interchangeable and their masses differ.
What does a certificate of analysis for CJC-1295 No DAC report?
A certificate for a batch of this material names the batch, names the issuing laboratory, and states for each parameter both the method used and the specification the result was measured against. Identity and purity are the two core results; net peptide content states how much of the fill weight is actually peptide.
A certificate belongs to a batch, not to a product line. When a new batch is released it is tested again, and the certificate published against it is that batch's certificate — a previous batch's result is never carried forward.
Is CJC-1295 No DAC for human use?
No. This page describes structure and analysis. It makes no claim about what this compound does, and none should be inferred from it. Material is supplied for laboratory research use only: it is not a drug, food, dietary supplement, cosmetic or medical device, it is not for human or veterinary consumption, and no dosing, administration or reconstitution guidance is provided for any such use.
References
- CJC-1295 — PubChem, National Library of Medicine
- Somatoliberin (GHRH) — human — UniProt Knowledgebase
- Cjc-1295 — ChEMBL, European Bioinformatics Institute
From the catalog
Compounds referenced on this page
For laboratory research use only. Not for human or veterinary consumption.